Product Highlights

Aspirin-FreeNo
Minimum Age12+ Years
Quantity300 ct.
VegetarianNo
Read More

Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

Item: 323464
(70)
Q & A (0)
300 Caplets
Easy to Swallow

$1999

($0.07/count)
FSA/HSA Eligible
Available Coupons

$3.00 off

(1) Advil OR Excedrin Item

Details

Expires: 11/15/2026


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  • In Stock
Health & Beauty | Aisle 1
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Smart Summary

Generated by AI
Fast Relief
Clinically proven headache relief can begin working in as little as 15 minutes for some individuals, providing rapid response when pain strikes.

Triple Action
Three complementary mechanisms work together—blocking pain signals, elevating pain threshold, and using caffeine as an amplifier—to deliver comprehensive relief.
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Product Overview

From the Brand
Details
Excedrin Extra Strength Pain Relief Caplets provide clinically proven headache relief fast. Excedrin works in three ways to relieve headaches. It blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect. Available in convenient caplet form, this nonprescription pain relief medicine works as hard as you do, combining aspirin and acetaminophen with caffeine. These active ingredients create a powerful formula with two pain relievers and a booster to offer temporary relief of pain from headaches, colds, premenstrual and menstrual cramps, arthritis, tooth pain and muscle pain. For some, headache pain relief with this Excedrin extra strength pain reliever can start in 15 minutes. Get headache relief fast with Excedrin, the headache expert.

Product Features:

  • One bottle of 300 Excedrin Extra Strength Pain Relief Caplets
  • Extra strength pain reliever that relieves pain associated with headache, colds, menstrual cramps, toothaches, muscular aches and arthritis
  • Excedrin Extra Strength works in three ways to relieve headaches: It blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
  • Pain medicine for adults that is a clinically proven headache pain reliever
  • Excedrin Extra Strength caplets contain two pain relievers and a booster for enhanced effect
  • Pain reliever available in convenient caplet form
  • For some, headache relief can start in 15 minutes
  • Includes pain relief caplets, 300 ct.
  • Ingredients: Active Ingredients: (in Each Caplet) Acetaminophen 250mg - Pain Reliever Aspirin 250 Mg (Nsaid*) - Pain Reliver Caffeine 65mg - Pain Reliever Aid *nonsteroidal Anti-inflammatory Drug. Other Inactive Ingredients: Benzoic ACID, Carnauba Wax, Fd&c Blue #1,hydroxypropylcellulose, Hypromellose, Light Mineral Oil, Microcrystalline Cellulose, Polysorbate 20, Povidone, Propylene Glycol, Simethicone Emulsion, Sorbitan Monolaurate, Stearic ACID, Titanium Dioxide.

    Product Warnings and Restrictions: Reye's Syndrome: Children and Teenagers WHO Have or Are Recovering From Chicken Pox or Flu-like Symptoms Should Not Use This Product. When Using This Product, if Changes in Behavior With Nausea and Vomiting Occur, Consult a Doctor Because These Symptoms Could Be an Early Sign of Reye's Syndrome, a Rare but Serious Illness. Allergy Alert: Acetaminophen May Cause Severe Skin Reactions. Symptoms May Include: Skin Reddening, Blisters, Rash if a Skin Reaction Occurs, Stop Use and Seek Medical Help Right Away. Allergy Alert: Aspirin May Cause a Severe Allergic Reaction Which May Include: Hives Facial Swelling Asthma (Wheezing) Shock Liver Warning: This Product Contacts Acetaminophen. Severe Liver Damage May Occur if You Take More Than 6 Caplets in 24 Hours, Which is the Maximum Daily Amount With Other Drugs Containing Acetaminophen 3 or More Alcoholic Drinks Every Day While Using This Product Stomach Bleeding Warning: This Product Contains an Nsaid, Which May Cause Severe Stomach Bleeding. The Chance is Higher if You Are Age 60 or Older Have Had Stomach Ulcers or Bleeding Problems Take a Blood Thinning (Anticoagulant) or Steroid Drug Take Other Drugs Containing Prescription or Nonprescription Nsaids (Aspirin, Ibuprofen, Naproxen, or Others) Have 3 or More Alcoholic Drinks Every Day While Using This Product Take More or for a Longer Time Than Directed Medication Overuse Headache Warning: Headaches May Worsen if This Product is Used for 10 or More Days Per Month. Caffeine Warning: The Recommended Dose of This Product Contains About as Much Caffeine as a Cup of Coffee. Limit the Use of Caffeine-containing Medications, Foods, or Beverages While Taking This Product Because Too Much Caffeine May Cause Nervousness, Irritability, Sleeplessness, and, Occasionally, Rapid Heartbeat. Do Not Use if You Have Ever Had an Allergic Reaction to Acetaminophen, Aspirin or Any Other Pain Reliever/fever Reducer With Any Other Drug Containing Acetaminophen (Prescription or Nonprescription). If You Are Not Sure Whether a Drug Contains Acetaminophen, Ask a Doctor or Pharmacist Ask a Doctor Before Use if You Have Never Had Migraines Diagnosed by a Health Professional You Have a Headache That is Different From Your Usual Migraines You Have the Worst Headache of Your Life You Have Fever and Stiff Neck You Have Headaches Beginning After or Caused by Head Injury, Exertion, Coughing or Bending You Experienced Your First Headache After the Age of 50 You Have Daily Headaches You Have a Migraine So Severe as to Require Bed REST You Have Liver Disease Stomach Bleeding Warning Applies to You You Have a History of Stomach Problems, Such as Heartburn You Have High Blood Pressure, Heart Disease, Liver Cirrhosis, or Kidney Disease You Are Taking a Diuretic You Have Asthma You Have Problems or Serious Side Effects From Taking Pain Relievers or Fever Reducers You Have Vomiting With Your Migraine Headache Ask a Doctor or Pharmacist Before Use if You Are Taking a Prescription Drug for: Diabetes Gout Arthritis Under a Doctor's Care for Any Serious Condition Taking Any Other Drug Taking Any Other Product That Contains Aspirin, Acetaminophen, or Any Other Pain Reliever/fever Reducer Stop Use and Ask a Doctor if an Allergic Reaction Occurs. Seek Medical Help Right Away. You Experience Any of the Following Signs of Stomach Bleeding: Feel Faint Vomit Blood Have Bloody or Black Stools Have Stomach Pain That Does Not Get Better Your Migraine is Not Relieved or Worsens After First Dose New or Unexpected Symptoms Occur Ringing in the Ears or Loss of Hearing Occurs if Pregnant or Breast-feeding, Ask a Health Professional Before Use. It is Especially Important Not to Use Aspirin During the Last 3 Months of Pregnancy Unless Definitely Directed to Do So by a Doctor Because It May Cause Problems in the Unborn Child or Complications During Delivery. Keep Out of Reach of Children. In Case of Overdose, Get Medical Help or Contact a Poison Control Center Right Away. (1-800-222-1222) Quick Medical Attention is Critical for Adults as Well as for Children Even if You Do Not Notice Any Signs or Symptoms.
    Shipping & Returns
    Reviews (70)
    4.9 out of 5

    Review Snapshot

    4.9
    70 ReviewsWrite a Review
    100%
    of respondents would recommend this to a friend

    Ratings Distribution

    Most Liked Positive Review

    Effective Headache Relief

    I keep a bottle of Excedrin Extra Strength (300 ct.) on hand at all times, and it has consistently been one of the fastest headache remedies I've used. Within about 15–20 minutes, I can usually feel the pressure start to ease, and before long the headache is either significantly reduced or completel...

    Versus

    Most Liked Negative Review

    Not bad

    I usually take Excedrin for headaches I've been taking Excedrin migraine which works great I tried to switch back to the regular Excedrin unfortunately it's not as good as the migraine one so I'm switching back

    Customers say

    Overall sentiment is strongly positive, with most reviewers saying this Excedrin-style pain relief works quickly for headaches and migraines and is their go-to option. The main outlier is a small number of users who find the regular version less effective than Excedrin Migraine.

    Reviewed by 70 customers

    Nice product

    Submitted 1 month ago

    By Al

    From Reading, PA

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Great for use with migraines and headaches. This is a great value and price and the supply lasts me almost a whole year.

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Execedrin

    Submitted 1 month ago

    By Sue

    From Millsboro

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Great for headaches. Large quantity great value

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Great headache relief

    Submitted 1 month ago

    By J.P.

    From Bohemia, NY

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    When taken with a full glass of water, works well

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Great

    Submitted 1 month ago

    By Stickballman 1

    From Valley Cottage NU

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Nothing else works for my headaches. Been using it for 40 years

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Aspirin

    Submitted 2 months ago

    By Ziggy

    From Danbury Ct

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Great product. Only thing that works for my wifes headaches.

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    #sweepstakes

    Submitted 2 months ago

    By Jk

    From Bridgeville Pa

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Great for headaches

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Excedrin

    Submitted 2 months ago

    By Kate

    From Casselberry, Florida

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Always works for aches and pains. Use it daily

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Headache

    Submitted 2 months ago

    By Roy C

    From NYC

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    For headaches, back pain, arthritis, or toothaches, Excedrin is better than Tylenol, don't forget to use the $3 off coupon.

    User submitted media
    Excedrin

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Best Headache Relief

    Submitted 2 months ago

    By Mike

    From Maple Shade, NJ

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Nothing works for us for headaches like excedrin.

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Great for pain

    Submitted 2 months ago

    By Day Day

    From Baltimore Maryland

    Verified Buyer

    Comments about Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.

    Takes two at a time for my headaches

    Bottom Line Yes, I would recommend to a friend

    Was this review helpful to you?

    Specifications
    Aspirin-FreeNo
    Minimum Age12+ Years
    Quantity300 ct.
    VegetarianNo
    Estimated Delivery3-5 Business Days
    Model Number300674349215
    upc300674349215
    Pain ReliefForm
    Active Ingredients(in each caplet) Acetaminophen 250 mg - Pain reliever. Aspirin 250 mg (NSAID*) - Pain reliever. Caffeine 65 mg - Pain reliever aid. *nonsteroidal anti-inflammatory drug
    CapsuleAge Range
    Count300
    Dosage Per Serving (mg/mcg)1 Caplet
    Net Weight0.53 lb.
    Product TypeAcetaminophen
    FormCaplet
    Age Range (Minimum Year & Up)12
    Multi-PackNo
    StrengthExtra Strength
    Caffeine-FreeNo
    Alcohol-FreeYes
    Gluten-FreeYes
    Sugar-FreeYes
    Q&A
    mgctlbxN$MSC mgctlbxV$2.0.55 mgctlbxL$C
    mgctlbxN$MZP mgctlbxV$5.3.7 mgctlbxL$C
    Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.
    Excedrin Extra Strength Pain Relief Caplets for Headache Relief, 300 ct.